Gwen Stacy is back in the webs and has an all-new, all-different mystery to solve: the reappearance of the Lizard! The Spider-Woman of Earth-65 was convinced that the Lizard died in her arms along with Peter Parker. But a new reptilian rampage leaves her with doubts not only about Peter's life, but his death as well. Troubles begin to mount as the Osborns of Gwen's world make their debut, and she finds herself on S.H.I.E.L.D.'s most wanted list! Perhaps some wise words from a mentor figure could help - how about Jessica Drew, the Spider-Woman of Earth-616? What lessons about power and responsibility will Jess have to share, and what use will they be when Gwen battles the Goblins?