Los Angeles, city of angels. Amnesiac and wounded, a mysterious femme fatale wanders on the sinuous road of Mulholland Drive. She finds shelter at Betty's house (Naomi Watts), an aspiring actress just arrived from her hometown and in search of stardom in Hollywood. Initially intrigued by the stranger who calls herself Rita (Laura Elena Harring), Betty discovers that her handbag is full of dollar bundles. The two women get to know each other better and decide to investigate in order to discover Rita's true identity... This slick, sinister, psycho-sexual thriller comes from the darkest recesses of Hollywood, a Los Angeles of strange dreams, unrequited love and a jealous burning rage.